The content of the vast majority of drug-drug interaction (DDI) decision support systems in the United States is created, maintained, and sold by drug knowledgebase vendors that use their own approach for evaluating and classifying the clinical importance of DDIs. Studies have demonstrated substantial variability in DDI alerting performance across electronic prescribing and pharmacy software systems. This paper describes recommendations by a work group to create a process to establish a standard set of DDIs for clinical decision support.

Tilson H, Hines LE, McEvoy G, et al. Recommendations for selecting drug-drug interactions for clinical decision supportAm J Health Syst Pharm. 2016;73(8):576–585. doi:10.2146/ajhp150565