Welcome to the DDI-CDS app page. Tools to improve patient safety are listed below. These are based on our CDS algorithms using open, free, and standards-based health information technology standards (SMART on FHIR).

The first app related to Warfarin and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is currently undergoing testing. If you are physician, pharmacist, or informaticist, we are interested in having you “test” drive the tool and completing a short survey. This app is a “shared-decision making” app – designed to have a healthcare professional have a discussion with a patient about the combination of the two medications.

The second app (Colchicine- CYP3A4/PGP inhibitors) is another tool to assist clinicians to assess the risk of harm when using these types of medications concurrently.  This tool is still under development and testing at this time.

Warfarin-NSAIDs Drug Interaction App (DDInteractTM )

DDI-CDS for Tizanidine – Cytochrome P-450 1A2 Inhibitors

DDI-CDS for Colchicine – Cytochrome P450 3A4/P-glycoprotein Inhibitors


Funding for developing the DDInteractTM came from grant U18 HS027099 from the Agency for Healthcare Research and Quality (AHRQ). Funding for developing the app for colchicine – cytochrome P450 3A4/P-glycoprotein inhibitors came from AHRQ grant R01HS025984.