Healthcare organizations, compendia, and drug knowledge base vendors use varying methods to evaluate and synthesize evidence on drug-drug interactions (DDIs). This situation has a negative effect on electronic prescribing and medication information systems that warn clinicians of potentially harmful medication combinations. A paper by Scheife et al. (see references below) provides recommendations for systematic evaluation of evidence from the scientific literature, drug product labeling, and regulatory documents with respect to DDIs for clinical decision support. Research on this topic is ongoing and stakeholders are suggested to read the companion articles listed below.

Scheife RT, Hines LE, Boyce RD, et al. Consensus recommendations for systematic evaluation of drug-drug interaction evidence for clinical decision support. Drug Saf. 2015;38(2):197–206. doi:10.1007/s40264-014-0262-8

Grizzle AJ, Hines LE, Malone DC, Kravchenko O, Hochheiser H, Boyce RD. Testing the face validity and inter-rater agreement of a simple approach to drug-drug interaction evidence assessment. J Biomed Inform. 2020 Jan;101:103355. doi: 10.1016/j.jbi.2019.103355. Epub 2019 Dec 12. PMID: 31838211

Seden K, Gibbons S, Marzolini C, Schapiro JM, Burger DM, Back DJ, Khoo SH. Development of an evidence evaluation and synthesis system for drug-drug interactions, and its application to a systematic review of HIV and malaria co-infection. PLoS One. 2017 Mar 23;12(3):e0173509. doi: 10.1371/journal.pone.0173509. eCollection 2017. PubMed PMID: 28334018; PubMed Central PMCID: PMC5363796.